Využití asociačních pravidel při analýze alarmových trendů

This article deals with acquired alarm logs analyses, the alarm logs from control systems, and explains the reasons for its collecting and implication of the analyses. Several existing platform solutions can be used to analyze the alarms from the historical trends, and solutions, which offer the filtering of events based on time units to obtain the data about the maximum and average number of logs. This paper contributes to this area by developing a graphical interface for a system that makes it possible to use the analysis by association rules and brings the possibility of detecting frequent and repeating patterns in acquired alarm data files.Tento článek se zabývá sběrem a analýzami alarmových logů, alarmových hlášení z řídicích systémů, a vysvětluje důvody pro jejich sběr a důsledky analýz. Několik stávajících řešení na softwarových platformách může být k analýze alarmů použito z ukládaných historických trendů a řešení, která nabízejí filtrování událostí na základě časových období a údajů o maximálním a průměrném počtu logů. Tento příspěvek přispívá k této oblasti vytvořením grafického rozhraní pro systém, který umožňuje použití analýzy pomocí asociačních pravidel a přináší možnost detekce častých a opakujících se vzorů v získaných datových souborech s alarmy

ABS Control Model

Import 04/07/2011Práca hovorí o rôznych typoch bŕzd ich výhodách a nevýhodách, vysvetľuje základne princípy brzdových a bezpečnostných subsystémov v automobile. Cieľom práce je objasniť funkciu a reakcie protiblokovacieho systému v súčasných automobiloch. Úvodná časť obsahuje popis elektronickej jednotky a rôzne modifikácie zapojenia systému, spôsobujúce zmenu správania pri brzdení. V ďalšej časti je rozpísaný návrh výučbového modelu slúžiaceho na overenie teoretických poznatkov v praxi. V závere práce je spravený rozbor jednotlivých simulácii vychádzajúcich z pohybových rovníc alebo z demo modelu. Tieto simulácie boli základom pre rozbor pulzov vychádzajúcich zo senzora kolesa. Práca je ukončená zhodnotením simulácií. Celkový text je zhotovený v publikovateľnej forme a bude využívaný ako študijná pomôcka.This project contains an information about various types of the brakes, their advantages and disadvantages, explains basic principles of breaking a safety systems in vehicle. The goal is to explain function and reactions of the antiblocking system in present vehicles. In the first part of the project, there is description of an electronic device and various modifications of plugging the system, causing change of behavior during the breaking phase. In the next part, there is model of educational device, used to confirm theoretical data in reality. In the final part, there is analysis of the simulations based on movement equations or a demo model. These simulations were critical for the analysis of pulses coming out of the sensor of the wheel. The project is concluded with summary of the simulations. Text in the project is written in the publishing form and can be used for educational purposes.352 - Katedra automatizační techniky a řízenívýborn

Stálá strukturovaná spolupráce a Evropská intervenční iniciativa jako předstupně jednotné evropské armády

Tato diplomová práce se zaměřuje na potenciál dvou nedávno spuštěných iniciativ, Stálé strukturované spolupráce a Evropské intervenční iniciativy, v kontextu možného vzniku jednotné evropské armády. S oběma iniciativami se pojila vysoká očekávání ohledně jejich příspěvku k pokračující integraci v oblasti obrany v Evropě. Pro výzkum těchto dvou iniciativ vytváříme unikátní teoretickou kategorizaci, která je založena na realistickém konceptu aliance a konstruktivistickém konceptu bezpečnostní komunity. Obě iniciativy jsou následně do kategorizace zasazeny s tím, že zjišťujeme, jaký konstruktivistický teoretický model pro studium obranné integrace se nejlépe hodí pro Stálou strukturovanou spolupráci a analogicky, jaký model je nejvhodnější pro Evropskou intervenční iniciativu. Na základě teoretických východisek je provedena empirická analýza obou iniciativ, díky níž zjistíme, jaké novinky přináší Stálá strukturovaná spolupráce a Evropská intervenční iniciativa do integrace v oblasti obrany. Zaměřili jsme se hlavně na systém jejich správy, institucionální strukturu a financování. Zvláštní pozornost byla věnována také konceptu sdílené suverenity. Práce je postavena na obsahové analýze primárních zdrojů a relevantní sekundární literatury.The master's thesis focuses on the potential of two recently launched initiatives, The Permanent Structured Cooperation and The European Intervention Initiative, to serve as preludes of the single European army. Both initiatives shared high expectations as vehicles for a relaunch of integration in defence domain in Europe, but do they really move the efforts in this respect forward? To study the two projects, we establish a unique theoretical measurement of defence and security integration, based on the realist concept of the alliance and constructivist concept of the security community. We then ask what constructivist theoretical model for the study of defence integration fits The Permanent Structured Cooperation best, and analogically, which archetype is the most suitable for The European Intervention Initiative. Based on the theoretical underpinnings, we carry out an empirical analysis of both initiatives to find out what novelties they bring to the area of defence. We focused mainly on their governance, institutional fabric and funding. Special attention was paid to varying level of pooled sovereignty. The thesis is built on the content analysis of primary sources and where appropriate on relevant secondary literature.Department of Security StudiesKatedra bezpečnostních studiíFakulta sociálních vědFaculty of Social Science

A Roman gilt finger ring from Přelouč and other Roman‑Period settlement finds

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The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells : Implications for COVID-19 vascular research

Humanized mouse models and mouse-adapted SARS-CoV-2 virus are increasingly used to study COVID-19 pathogenesis, so it is impor-tant to learn where the SARS-CoV-2 receptor ACE2 is expressed. Here we mapped ACE2 expression during mouse postnatal development and in adulthood. Pericytes in the CNS, heart, and pancreas express ACE2 strongly, as do perineurial and adrenal fibroblasts, whereas endothelial cells do not at any location analyzed. In a number of other organs, pericytes do not express ACE2, including in the lung where ACE2 instead is expressed in bronchial epithelium and alveolar type II cells. The onset of ACE2 expression is organ specific: in bronchial epithelium already at birth, in brain pericytes before, andin heart pericytes after postnatal day 10.5. Establishing the vascular localization of ACE2 expression is central to correctly interpret data from modeling COVID-19 in the mouse and may shed light on the cause of vascular COVID-19 complications.Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The genetics of the mood disorder spectrum:genome-wide association analyses of over 185,000 cases and 439,000 controls

Background Mood disorders (including major depressive disorder and bipolar disorder) affect 10-20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Despite their diagnostic distinction, multiple approaches have shown considerable sharing of risk factors across the mood disorders. Methods To clarify their shared molecular genetic basis, and to highlight disorder-specific associations, we meta-analysed data from the latest Psychiatric Genomics Consortium (PGC) genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; non-overlapping N = 609,424). Results Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are novel for mood disorders. More genome-wide significant loci from the PGC analysis of major depression than bipolar disorder reached genome-wide significance. Genetic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single episode major depressive disorder. Systems biology analyses highlight both similarities and differences between the mood disorders, particularly in the mouse brain cell-types implicated by the expression patterns of associated genes. The mood disorders also differ in their genetic correlation with educational attainment – positive in bipolar disorder but negative in major depressive disorder. Conclusions The mood disorders share several genetic associations, and can be combined effectively to increase variant discovery. However, we demonstrate several differences between these disorders. Analysing subtypes of major depressive disorder and bipolar disorder provides evidence for a genetic mood disorders spectrum

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.

Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development

Czechoslovak policy towards the Greek minority between 1948-1968

This bachelor thesis deals with the Czechoslovak policy towards the Greek minority between the years of 1948 and 1968. During and after the Greek Civil War thousands of Greek refugees, mostly sympathizers with the communist left, found shelter in Czechoslovakia. The Greek political emigration came to Czechoslovakia mainly between 1948 and 1950, when the country was still economically harmed by the Second World War. Czechoslovakia was also harmed demographically by huge transfers of population which had been made shortly before the arrival of Greek emigrants. The principal goal of this thesis is to answer the following questions: Why did Czechoslovakia hold variable approach towards Greek minority between 1948- 1968 and whether there were differences between officially proclaimed policy of Czechoslovakia (in the constitution and laws) and real approach towards the Greek minority